ea0073oc11.6 | Oral Communications 11: Adrenal and Cardiovascular Endocrinoloyg | ECE2021
Warde Kate
, Yi Jan Lim
, Beuschlein Felix
, Constanze Hantel
, Conall Dennedy Michael
IntroductionAdrenocortical Carcinoma (ACC) is a rare aggressive cancer which carries a poor prognosis. Adjuvant mitotane improves survival but is limited by poor response rates and resistance following tumour recurrence. Mitotanes efficacy has been attributed to intracellular accumulation of toxic free cholesterol (FC) predominantly through inhibition of cholesterol storage through SOAT1. Yet SOAT1 specific inhibitors demonstrate inferior efficacy ...